Nationwide springs pleasant surprise for house sellers and builders

first_imgTo continue enjoying Building.co.uk, sign up for free guest accessExisting subscriber? LOGIN Subscribe now for unlimited access Stay at the forefront of thought leadership with news and analysis from award-winning journalists. Enjoy company features, CEO interviews, architectural reviews, technical project know-how and the latest innovations.Limited access to building.co.ukBreaking industry news as it happensBreaking, daily and weekly e-newsletters Get your free guest access  SIGN UP TODAY Subscribe to Building today and you will benefit from:Unlimited access to all stories including expert analysis and comment from industry leadersOur league tables, cost models and economics dataOur online archive of over 10,000 articlesBuilding magazine digital editionsBuilding magazine print editionsPrinted/digital supplementsSubscribe now for unlimited access.View our subscription options and join our communitylast_img read more

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TRANSY moves space equipment

first_imgThe dangerous cargo (IMO class 1) consisted of 21 specialised oversized containers and 30 standard containers, flat racks, tank containers. Additional equipment and rocket fuel was transported from Moscow and Samara to the port of St Petersburg by rail and truck, and then installed and mounted by Transy specialists. Specially-designed trailers and cradles were used prior to loading onboard a ro-ro vessel with the assistance of two shoreside cranes.last_img

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Bill Gates’ newest mission: Curing Alzheimer’s

first_img Bill Gates is leaving Microsoft and Berkshire Hathaway’s boards Bill Gates’ newest mission: Curing Alzheimer’s Published: November 13, 2017 8:28 AM EST SHARE NEW YORK (CNN) It’s one of the holy grails of science: a cure for Alzheimer’s. Currently, there is no treatment to stop the disease, let alone slow its progression. And billionaire Bill Gates thinks he will change that.“I believe there is a solution,” he told me without hesitation.“Any type of treatment would be a huge advance from where we are today,” he said, but “the long-term goal has got to be cure.”I had the chance to sit down with Gates recently to talk about his newest initiative. He sat in front of our cameras exclusively to tell me how he hopes to find a cure to a disease that now steals the memories and other cognitive functions of 47 million people around the world.For Gates, the fight is personal. He is investing $50 million of his own money into the Dementia Discovery Fund, a private-public research partnership focused on some of the more novel ideas about what drives the brain disease, such as looking at a brain cell’s immune system. It’s the first time Gates has made a commitment to a noncommunicable disease. The work done through his foundation has focused primarily on infectious diseases such as HIV, malaria and polio.I have interviewed Gates many times over the years, in countries around the world. He was more engaged on this topic of Alzheimer’s than I’ve ever seen before.Today, Alzheimer’s disease is the most common form of dementia and the sixth leading cause of death in the United States, where a new case is diagnosed every 66 seconds. More than 5 million Americans live with the disease, at a cost of $259 billion a year. Without any treatment, those numbers are projected to explode to 16 million Americans with the disease, at a cost of over $1 trillion a year, by 2050.“The growing burden is pretty unbelievable,” the tech guru-turned-philanthropist told me. It’s something he knows personally. “Several of the men in my family have this disease. And so, you know, I’ve seen how tough it is. That’s not my sole motivation, but it certainly drew me in.”When he said, “I’m a huge believer in that science and innovation are going to solve most of the tough problems over time,” I could feel his optimism.He told me he has spent the past year investigating and talking to scientists, trying to determine how best to help move the needle toward treatment of the disease itself rather than just the symptoms.A disease turns 100It has been more than a century since the disease was identified by German physician Dr. Alois Alzheimer. He first wrote about it in 1906, describing the case of a woman named “Auguste D.” Alzheimer called it “a peculiar disease,” marked by significant memory loss, severe paranoia and other psychological changes.But it wasn’t until Alzheimer performed an autopsy on her brain that the case became even more striking. He found that her brain had shrunk significantly, and there were unusual deposits in and around the nerve cells.It would take another 80 years for scientists to identify what those deposits were: plaques and tangles of proteins called amyloid and tau. They have become hallmarks of the disease.Both amyloid and tau are naturally occurring proteins that can be found in healthy brain cells. But in a brain with Alzheimer’s, something goes haywire, causing parts of amyloid proteins to clump together and block the cell’s messaging pathways. Eventually, tau proteins begin to tangle up inside the neurons.All of this contributes to a breakdown of the neural highway that helps our brain cells communicate. These changes in the brain can begin years before anyone starts actually exhibiting any symptoms of memory loss or personality changes.Until recently, it’s been a challenge to understand the disease, let alone identify who has it. The only way to definitively diagnose Alzheimer’s is still after someone has died and their brain can be examined under the microscope, looking for the telltale amyloid plaques and tau tangles.A new hope“It’s gone slower than we all would have hoped. A lot of failed drug trials,” Gates told me. And he’s right. Since 2002, there have been more than 400 Alzheimer drug trials run and yet no treatments. There are some drugs prescribed to help with cognitive symptoms such as memory loss or confusion but nothing that actually targets Alzheimer’s.In the past five years, advanced imaging technology has allowed us to see tau and amyloid in living people.Dr. James Hendrix, who heads up the Alzheimer Association’s Global Science Innovation team, believes that this development is a game-changer. “You need good tools to find the right therapeutics,” he said.By identifying these biomarkers earlier, Hendrix told me, scientists can work on finding ways to prevent the brain from deteriorating.“If we can catch the earliest signs of Alzheimer’s, then we’re treating a mostly healthy brain, and keeping it mostly healthy. … It’s very difficult to repair the damage once it’s done,” he explained.Dr. Rudy Tanzi agrees that imaging has been essential in understanding the pathology of Alzheimer’s and potential treatments. Tanzi, a professor of neurology at Harvard, has been at the helm of Alzheimer’s research, discovering several of the genes associated with the disease.He points out that one of the greatest faults with some of the trials has not been in the treatment itself but in the application: too late in the disease’s progression, when symptoms are already occurring. “It’s like trying to give someone Lipitor when they have a heart attack,” he explained. “You had to do it earlier.”Tanzi said we need to think about Alzheimer’s like cancer or heart disease. “That’s how we’re going to beat the disease: early detection and early intervention.”Think differentMost of the focus in Alzheimer’s research has been on tau and amyloid, what Gates likes to call “the mainstream.” With his donation, Gates hopes to spur research into more novel ideas about the disease, like investigating the role of the glial cells that activate the immune system of the brain or how the energy lifespan of a cell may contribute to the disease.“There’s a sense that this decade will be the one that we make a lot of progress,” Gates told me.Gates believes that it will be a combination of mainstream and out-of-the-box thinking that will lead to potential treatments in the near future.“Ideally, some of these mainstream drugs that report out in the next two or three years will start us down the path of reducing the problem. But I do think these newer approaches will eventually be part of that drug regimen that people take,” he said.Has looking into Alzheimer’s research caused Gates to worry about his own health?“Anything where my mind would deteriorate” is, he said, one of his greatest fears. He’s seen the hardship it has caused in his own family. “I hope I can live a long time without those limitations.”So Gates is now focused on prevention, by exercising and staying mentally engaged. “My job’s perfect, because I’m always trying to learn new things and meeting with people who are explaining things to me. You know, I have the most fun job in the world,” he said with a smile. Author: CNN Do you see a typo or an error? Let us know. Recommended Bill Gates explains how the US can safely ease coronavirus restrictions last_img read more

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Rio declares “state of calamity” over floundering finances on eve of Olympics

first_img Share 43 Views   no discussions MoneyNewsRegionalSports Rio declares “state of calamity” over floundering finances on eve of Olympics by: Caribbean 360 – June 20, 2016 Share Tweetcenter_img The decree authorizes the state to adopt all necessary emergency measures to ration essential public services in order for the Rio 2016 Olympics and Paralympic Games to take place.RIO DE JANEIRO, Brazil, Monday June 20, 2016 (Caribbean 360)– Rio state authorities have declared “a state of public calamity,” warning that extreme economic measures would need to be implemented to successfully host the Olympic Games due to begin in August.The decree authorizes the state to “adopt all necessary emergency measures to ration essential public services in order for the Rio 2016 Olympic Games and Paralympic Games to take place.”The statement, published late Friday on the state government’s web site, said that emergency actions are necessary to avoid a “total collapse in public safety, health, education, transport and environmental management.”“Any institutional instability would hurt the country’s image,” said the decree, signed by acting governor Francisco Dornelles.Rio de Janeiro state is in financial difficulties due to the fall in global oil prices, while Brazil overall is floundering through a deep recession.Civil servants in Rio state have suffered pay cheque delays because of the cash crunch, while retirees are grappling with the hardships posed by unpaid pensions.Brazil has been mired in recession for the past two years, making it hard to fund the estimated US$10 billion the country is spending on Olympic venues and infrastructure projects to support the Games.Those costs have contributed to widespread protests throughout Brazil, as citizens complain that the money should be spent on hospitals, schools and emergency services instead.While Friday’s statement did not specify what emergency actions were necessary, it made it clear that without them the event would be jeopardized.According to the statement: “It is for the competent authorities to adopt exceptional necessary measures to rationalize all public services, with the aim of realizing the Games.”Brazil has suffered economic and political chaos, not to mention the ravages of the Zika virus, leading up to the Games, which were awarded to Rio when the country was enjoying boom times.As a leading world supplier of natural resources, Brazil has been severely impacted by the global economic slowdown, which has seen commodity prices plummet.Adding to the economic woes is leadership upheaval. President Dilma Rousseff was suspended last month by the Brazilian Senate, which will hold an impeachment trial on charges that she violated spending accounting rules.In the meantime, many of the country’s top politicians have been ensnared in a bribery corruption scandal involving the state-run oil company Petrobras.Corruption charges also have swirled around interim President Michel Temer, who had been vice president prior to Rousseff’s suspension, and there has been a steady shuffling of top government officials.The economic and political problems have sparked mass protests by supporters and opponents of Rousseff, and there is concern that new demonstrations could cause disruption for visitors attending the games.The August 5-21 Olympics and September 7-18 Paralympics in Rio de Janeiro are the first to be held in South America. Share Sharing is caring!last_img read more

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Farmington Hills ‘Paw Watch’ training set November 8

first_imgFarmington Hills pet owners are invited to a November 8 training designed to help them take an active role in keeping their city safe.The Paw Watch meeting starts at 6 p.m. at Police Headquarters, 31655 W. 11 Mile Rd., just west of City Hall.Pet owners (pets do not attend) learn how to observe suspicious activities or criminal behavior, find out what type of information the Police Department is seeking, and get tips on how to report information that helps officers respond to incidents. Participants will also learn how to remain safe when they are out walking their pets.The Paw Watch meeting is open to all residents. Every pet who joins the program will receive a Paw Watch bandana. Light refreshments will be served, and a special safety prize will be awarded in a raffle held at the end of the meeting.To register or learn more, contact the Crime Prevention Section at 248-871-2750 or write to crimeprevention@fhgov.com.Get more local headlines sent toyour inbox every morning (except Sunday). Reported by admin Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Pinterest (Opens in new window)last_img read more

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Local Spotlight: Introducing The Fighting Pride Of Mansfield

first_img Related TopicsAntonio NievesBoxingChaise Nelson Northeast Ohio continues to be a hotbed for professional fighters.  Chaise Nelson is no exception to that rule.  He screams “prodigy” and always lets his fists do the talking in the ring.  Nelson is the fighting pride of Mansfield, Ohio and has the world in his young hands as he makes a gigantic name for himself in the boxing world.  Nelson’s pro career is off to a hot start at 6-1 with 3 knockouts.  His sole loss is a highly disputed and contested split decision defeat to Brandon Benetiz.As an amateur, Nelson went 124 – 8 as and was a 9x National Champion as part of Team USA.He was ranked #1 in the world in 2013 and Represented the US in Kiev Ukraine for the 2013 Jr. World Championships.At 18, he signed with Old Kings Promotions and it easily billed as a future World champion.Nelson has the pedigree, the heart and the hustle to do big things in the world of Boxing.  He spars with Antonio Nieves who is also going for gold this weekend himself on HBO.Nelson gets up at 4:30 am to train most days and follows a strict diet as he stays in tip top shape.  At 18, weighing 126 lbs, he trains 6 days a week and sticks to that strict diet of lots of carbs, vegetables and fruit.Nelson is on the rise! Vince McKeelast_img read more

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Indians trading for Hand and Cimber is a move for both the present and the future

first_img Related TopicsAdam CimberBrad HandChris AntonettiClevelandCleveland IndiansFrancisco MejiaIndiansMLBSan Diego Padres Ashley Bastock Ashley is a former basketball player who covers the Cleveland Cavaliers, Indians and high school sports for NEO Sports Insiders. She also covers the Cavs for SB Nation’s Fear The Sword. Ashley is a 2015 graduate of John Carroll University and previously worked in political journalism. You can follow her on Twitter @AshleyBastock42center_img CLEVELAND– On Wednesday afternoon, as Indians president of baseball operations Chris Antonetti was working out the final details of a trade to acquire San Diego relievers Brad Hand and Adam Cimber, he wasn’t in his office or a conference room.“I was zip lining with my younger daughter,” he said. “So we had multiple trade conversations going not only with San Diego but with a few other teams. That was a place she wanted to go around the All-Star break, it was the one day we were getting away.“Thankfully at least I had a harness, so I wasn’t in danger of falling off the platform.”And while he was in one of the most unconventional locations possible sorting out the final details of the trade on Wednesday, Antonetti pulled off the kind of deal that has become his M.O. over recent years– the kind that helps the Tribe both now and in the future.Yes, even though that meant giving up the team’s top prospect in catcher Francisco Mejia.“Really tough to trade Francisco,” Antonetti said in a press conference with reporters on Thursday. “It’s a guy that we think has a chance to be a really good Major League player, but in order to get back players like Brad Hand and Adam Cimber who have multiple years of control, we knew we were going to have to part with considerable talent and we did that in trading Francisco.”And in the end, that control is what makes Hand and Cimber so valuable. Sure, Antonetti has made deals before for players who ended up being rentals (Jay Bruce, Joe Smith), but oftentimes he makes deals for guys that the Indians will get to keep under contract in the years to come– think the Ubaldo Jimenez trade in 2011 and the Andrew Miller trade in 2016.Now with this latest deal, it is more of the same. Hand is locked up for the next few seasons as he signed a three-year, $19.75 million extension in 2018 that has a club option for 2021. The Indians will have Cimber under their control until the 2024 season when he’s 33 years old.Ultimately, with the length of time on Hand and Cimber’s contracts, combined with their talent and the Tribe’s desperate need for some bullpen help, it was practically a deal that was too good to pass up, even though it meant parting ways with Mejia.“I think we’ve talked at different junctures in the past at taking a multi-year approach to team building, and we’ve placed a premium at acquiring guys that not only can impact one season but a handful of seasons,” Antonetti said. “As we looked at our roster, we know that there are a handful of players that are on expiring contracts, and a few of them in the bullpen, so one of the things we’ve sought to do, dating back to spring training and extending through the deadline and continues to be a focus for us is acquire guys that can help us in the bullpen beyond this year, and both Brad and Adam should do that.”Hand is an All-Star with 24 saves so far this season and a 3.05 ERA through 41 appearances. This season, he’s amassed 65 strikeouts. Cimber uses a unique low slot delivery (think Brad Ziegler or Darren O’Day) and is 3-5 with a 3.17 ERA this season in 42 games, 48.1 innings for the Padres. He offers some versatility to the pen as a right-hander who can strike out right-handed batters.What exact roles they will settle into remains to be seen, but it wouldn’t be surprising to see Hand split time closing with Cody Allen, and see a lot of time in late innings even if Allen is being used in the ninth. And if Allen decides to walk after this season, it certainly doesn’t hurt to have Hand, who has plenty of experience games in high-leverage situations, already locked up.“I think what we’ve tried to do is build a deep and versatile bullpen and we think both of these guys will fit into that mix and give (Terry Francona) a couple of additional options to get outs late in the game,” Antonetti said. “Exactly how we use them and what roles they’ll settle into, we’ll see that evolve over the course of the next few weeks and next few months.”last_img read more

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School starts today for students from 1st grade and up

first_imgJACKSBORO, TN (WLAF) – The first full week of school begins today for students from Grades 1 through 12.  (WLAF NEWS PUBLISHED – 08/17/2020-6AM)Share this:FacebookTwitterlast_img

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Liverpool legend: Sterling has shown the club respect

first_imgFollow West London Sport on TwitterFind us on Facebook Liverpool legend Robbie Fowler has hailed Raheem Sterling for his attitude since breaking into the first team at Anfield.The 18-year-old from Harlesden is close to signing a new contract and despite speculation about his future has continually indicated that he wants to stay at the club.And Fowler told the Daily Mirror: “It’s so easy these days for kids to believe their own publicity.“But I watch Raheem and I can see he has respect for the team and for the senior players around him.“And his decision-making is good – he doesn’t just want to beat players and then shoot to get personal glory.“I think the manager has to take some credit in that development. He’s still a kid and got a long way to go – he needs to improve his final ball.“But Brendan Rodgers has already proved himself as a coach at the top level, and he’s in the right hands.”See also: Sterling set to sign new contractSterling should commit his future to Liverpool, says 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last_img read more

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U of San Francisco new logos

first_imgDC in Da House w/o a Doubt Link to post Link to post Sports Logos 6,236 posts 186 raysox Followers 0 Posted August 17, 2012 Link to post Forums Home Members 450 7,146 Sports Link to post Share on other sites jgladding Link to post 0 Downgrade. It doesn’t even really rep the city right. A very lazy attempt at the bridge. Villain I like how the U looks like a field goal post. Should be on the football teams helmets, that is if they have one, I don’t know. 0 0 186 Pretty underwhelming… the logo is a definite downgrade. 0 Raider Nation Location:The DMV 3,972 Members Members Posted August 17, 2012 909 Sports Logos Location:St. Petersburg, FL TrueYankee26 Share on other sites walkerws 909 12,366 posts 5,731 posts Link to post 186 6,585 posts 18 I like how the U looks like a field goal post. Should be on the football teams helmets, that is if they have one, I don’t know.They haven’t fielded a football team in quite a while. Generic font, but overall not bad. I love the golden gate logo tho. raysox All Activity 909 Sign in to follow this   Share this post Definite upgrade by the WCC rivals. The old set was overly cartoony. What if there were no hypothetical questions? $1 Cans of PBR Followers 0 2,271 2,699 posts 18 19 Recommended Posts SportsLogos.Net Posted August 19, 2012 Sign in to follow this   7,190 posts 450 Share on other sites DarkJourney Spearhead Share this post Link to post 3,583 6,822 posts 185 posts Share this post 54 10 Members Moderators http://www.csnbayarea.com/ncaa/news/USF-unveils-new-logos-website?blockID=758387&feedID=2539&awid=9182286363521190982-766 Members Link to post TrueYankee26 Members bosrs1 Location:Louisville, KY Favourite Logos:Kent State, Columbus Crew, Columbus Blue Jackets primary Share on other sites 1,288 Spearhead Share on other sites 26,933 posts 10,452 posts Posted August 18, 2012 Posted August 17, 2012 0 Do you has the five bucks? 54 Posted August 17, 2012 Members Share this post U of San Francisco new logos Location:Massillon, OH Members Share this post LMU Share this post 0 DCDuck Link to post 0 Forums Home 2,271 Link to post Location:Republic of Texas Members Old School Fool 18 10 Share this post 54 3,972 Sapphire Old School Fool By jgladding, August 17, 2012 in Sports Logo News Link to post meetthemets 7,146 246 posts 3,972 Location:California All Activity As per Wikipedia: The 1951 University of San Francisco Dons football team,coached by Joe Kuharich, went undefeated, with a record of 9-0, and the team produced ten future NFL players (Ollie Matson, Gino Marchetti, Bob St. Clair, Dick Stanfel, Ed Brown, Lou Stephens, Burl Toler, Joe Scudero, Roy Barni, Mike Mergen, Merrill Peacock, and Ralph Thomas). Five became NFL Pro-Bowlers, and Gino Marchetti, Ollie Matson, and Bob St. Clair later were inducted into the NFL Hall of Fame?a record for one college team. The team also had another first; Burl Toler became the first African American official in the NFL. Future NFL Commissioner Pete Rozelle played a role as the Dons’ Athletic Publicist. At the height of their success, the team experienced one of the greatest snubs in college football history. Due to the team having two African-American star players, Ollie Matson and Burl Toler, they were not invited to play in any of the college football bowl games hosted by the SEC (Southern Conference). This resulted in the team being invited to the Orange Bowl without Toler and Matson. The team refused the invitation. Guard Dick Columbini said “‘No, we’re not going to leave ?em at home? … ?We’re going to play with ?em or we?re not going to play. As a result of the team’s refusal to play in the Orange Bowl, the USF Athletic Department was forced to drop its football program in 1952, due to a deficit in department funds. Share this post Members DCDuck 19 LMU Posted August 19, 2012 0 walkerws 0 Posted August 17, 2012 I can’t imagine what SME was paid for that. Very uninspired. Just another example of big design firms doing lazy work and (probably) getting paid a ton of dough. Someone from this board could have done this in 3 seconds. Location:Torrance, California jgladding 1,288 450 Share this post Posted August 17, 2012 Share on other sites 3,583 10 3,583 Share on other sites Share this post 0 Favourite Logos:USFL’s Florida Tuskers Displaced Washingtonian 0 Share on other sites Sapphire DC in Da House w/o a Doubt Share this post 0 Share on other sites Sports Logo News 0 bosrs1 Meh…The WCC as a whole has had a run of pretty “meh” rebrands in the past few years. Members 1,288 Posted August 17, 2012 Location:San Diego Posted August 21, 2012 Pretty underwhelming… the logo is a definite downgrade.Agreed. Terribly generic downgrade over this one. Particularly the “fieldgoal” logo. Those look pretty terrible imo. Downgrades for sure. Share this post 0 Share on other sites Link to post DarkJourney 7,146 Share on other sites 1,296 posts U of San Francisco new logos SportsLogos.Net Posted August 19, 2012 Share on other sites Posted August 21, 2012 This one I like. 0 2,271 2,019 posts meetthemets Link to post 19 0 This topic is now closed to further replies. Go To Topic Listing Share on other sites Members Share this post Sports Logo News U of San Francisco new logoslast_img read more

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